The problem of global TB and the failure to reach targets for TB control, results in the deaths each year of nearly one and a half million people. Deaths from a disease that for many years has been treatable and curable.1“Global Tuberculosis Control 2011”, WHO, Geneva, 2011, 9 www.who.int/tb/publications/global_report/ It is not clear though whether this continuing high level of deaths is due to a failure of global TB control strategies, the impact of the joint TB and HIV epidemics, the increasing problem of drug resistant TB, a lack of TB funding or more likely a combination of all four.
“We have known how to cure TB for more than 50 years. What we have lacked is the will and the resources to quickly diagnose people with TB and get them the TB treatment they need.”
Nelson Mandela July 15, 2004 2Remarks by Nelson Mandela: “Confronting the Joint HIV/TB Epidemics”, XV International AIDS Conference, Bangkok, 2004 http://quod.lib.umich.edu/c/cohenaids/
Each year, for those people with pulmonary TB the following can often be true:
“When TB wakes up and gets into the lungs, it eats them from the inside out, slowly diminishing their capacity, causing the chest to fill up with blood and the liquidy remains of the lungs. A wet, hacking cough is evocative of TB. The lungs now in liquid form are sloshing around in the chest. Cough that up, even in microscopic, impossible to see droplets, near other people, and they have a very good chance of getting TB too.”
“Eventually, liquid replaces the lungs, the suffering patients cannot get enough oxygen, and respiratory failure occurs, they can no longer breathe and they drown. It’s painful, it’s drawn out. It’s an awful way to die. But before any of this happens the disease weakens you, diminishes your capacity for work, and puts your family and friends, and anyone else you come into contact with, at risk. Individual death is only part of the problem.”
Christian W. McMillen, Discovering Tuberculosis
In 1993 the World Health Organisation (WHO) declared TB to be a global emergency saying that:
“Tuberculosis today is humanity’s greatest killer, and it is out of control in many parts of the world. The disease, preventable and treatable, has been grossly neglected and no country is immune to it.”
Arati Kochi, Manager WHO Tuberculosis Program 3“WHO Calls Tuberculosis a Global Emergency”, Los Angeles Times, 1993 //articles.latimes.com/1993
Subsequently WHO in the mid 1990s further developed their “DOTS”, or Directly Observed Treatment Short course strategy. This was to become the internationally recommended approach to TB control until 2006. The strategy was built on model programmes developed in African countries from the late 1980s and subsequently expanded worldwide.
DOTS has five components, which were initially as follows.4“What is DOTS? WHO Tuberculosis Factsheet”, WHO, 2006 What is dots?
By the year 2000 some global TB targets set in 1991 had not been met. So further international meetings were held, at which the same goals were once again set, but this time to be achieved by 2005.5“Amsterdam Declaration to Stop TB”, Amsterdam, The Netherlands, 24th March 2000 www.stoptb.org/assets/documents/events/meetings/amsterdam_conference/decla.pdf
At a meeting in Amsterdam in March 2000, the 20 “high burden” TB countries again confirmed their commitment to meeting, amongst other goals, the detection of 70% of active TB cases, this time to be achieved by 2005.6“Amsterdam Declaration to Stop TB”, Amsterdam, The Netherlands, 24th March 2000 www.stoptb.org/assets/documents/events/meetings/amsterdam_conference/decla.pdf
In the eighteen months after the Amsterdam Declaration a number of global TB initiatives were to be started. These included:7“First Stop TB Partners’ Forum”, Washington, 22 October 2001, 6 www.stoptb.org/events/meetings/partners_forum/2001/
The Stop TB partnership was set up in 2001 following the Amsterdam Conference in 2000. Initially the partnership comprised just six organisations and one of its first initiatives was the Global Drug Facility.
The Global Drug Facility was established in 2001 to expand access to and the availability of high quality TB drugs, in order that DOTS programs could be expanded. It was established in response to the difficulties that countries had in the 1990s in finding and funding high quality supplies of TB drugs. It was believed that patients were developing resistance as a result of poor quality drugs.8“What is the GDF?”, www.stoptb.org/gdf/
In 2000 the WHO and some international partners, were beginning to develop an initiative called DOTS-Plus. It was considered that the development of the DOTS strategy had been very successful in expanding effective TB treatment. However in some areas its success was being threatened by the emergence of multi drug resistant TB. DOT-Plus was to be developed as a comprehensive initiative that was to build upon the five elements of DOTS, but would take into account specific issues, such as the use of second line anti TB drugs, that needed to be used in areas where there were significant levels of MDR TB.
One of the difficulties with the implementation of some of the DOTS-Plus pilot projects, was the need for quality second line anti TB drugs, which were normally very expensive. WHO and their partners made an arrangement with the pharmaceutical industry for preferential prices for second line drugs used for the pilot projects. However, it was considered important that these beneficial prices were only used in projects that were organised according to certain standards. So the Green Light Committee was established to review project applications, and to decide whether they were sufficiently in accordance with the guidelines that had been established for the pilot projects.9“DOTS-Plus & the Green Light Committee”, www.who.int/tb/publications/2000/en/index.html
The Global Alliance for Tuberculosis Drug Development (now called the TB Alliance) was launched in October 2000, at a time when there were no TB drugs in clinical development. Since then the resulting organisation has, amongst other things, launched the first clinical trial to test multiple new drugs, and co–founded the Critical Path to TB Drug Regimens (CPTR) initiative.10“TB Alliance History and Impact”, http://www.tballiance.org/about/history.php
By the time the first Stop TB Partners’ Forum took place in October 2001 the partnership had grown from six to over 120 organisations. At the Forum the launch took place of the Global Plan to Stop TB 2001–2005. Its aim was to provide a “roadmap” towards a TB free world, and it was considered that the 2005 TB control targets were realistic.11“First Stop TB Partners’ Forum”, Washington, 22 October 2001, 6 www.stoptb.org/events/meetings/partners_forum/2001/
The Global Plan to Stop TB 2001–2005 made a number of commitments including that:12“First Stop TB Partners’ Forum”, Washington, 22 October 2001, 6 www.stoptb.org/events/meetings/partners_forum/2001/
Once again the targets set in a Global Plan to Stop TB had not been reached. This time it was the targets in the Global Plan to Stop TB 2001–2005, and these targets had been considered realistic back when they were set in 2001.
In the new global plan for 2006–2015, the targets were no longer set in terms of the percentage of people reached in case detection rates, or a treatment success rate of at least 85%. Instead there were a range of targets covering specific areas such as the development of improved diagnostics and drugs, and the target set in the Millenium Development Goals.
The Global Plan to Stop TB 2006–2015 has as its main targets:13“The Global Plan to Stop TB 2006-2015”, WHO, Geneva, 2011, 9 www.stoptb.org/global/plan/
In 2009 the Stop TB Partnership produced a report on the progress that had been made in global TB control between 2006 and 2008.14“The Global Plan to Stop TB 2006-2015: Progress Report 2006-2008”, WHO, 2009 www.stoptb.org/resources/publications/plans_strategies Many different areas were highlighted and in some, significant progress had been made, whereas in others, such as screening HIV positive people for TB, it was noted that much less progress had occurred. It was particularly noted that the provision of funding for TB was an area of particular difficulty with a funding gap still existing of over US$1 billion per year.
The Global Plan was subsequently updated in 2010, to become the “Global Plan to Stop TB 2011–2015”.15“The Global Plan to Stop TB 2011-2015”, WHO, Geneva, 2010 www.stoptb.org/global/plan/
In 1993 the WHO declared TB to be a global emergency, stating that the disease would claim more than 30 million lives in the next ten years unless sufficient action was taken. Since then some action has been taken, but TB still claims one and a half million lives a year, and more than 30 million people have died since the global emergency was declared. What was said by WHO in 1993 is still probably true today.
“Tuberculosis today … is out of control in many parts of the world. The disease, preventable and treatable, has been grossly neglected and no country is immune to it.”
Arati Kochi, Manager WHO Tuberculosis Program 16“WHO Calls Tuberculosis a Global Emergency”, Los Angeles Times, 1993 //articles.latimes.com/1993
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|1.||↑||“Global Tuberculosis Control 2011”, WHO, Geneva, 2011, 9 www.who.int/tb/publications/global_report/|
|2.||↑||Remarks by Nelson Mandela: “Confronting the Joint HIV/TB Epidemics”, XV International AIDS Conference, Bangkok, 2004 http://quod.lib.umich.edu/c/cohenaids/|
|3.||↑||“WHO Calls Tuberculosis a Global Emergency”, Los Angeles Times, 1993 //articles.latimes.com/1993|
|4.||↑||“What is DOTS? WHO Tuberculosis Factsheet”, WHO, 2006 What is dots?|
|5.||↑||“Amsterdam Declaration to Stop TB”, Amsterdam, The Netherlands, 24th March 2000 www.stoptb.org/assets/documents/events/meetings/amsterdam_conference/decla.pdf|
|6.||↑||“Amsterdam Declaration to Stop TB”, Amsterdam, The Netherlands, 24th March 2000 www.stoptb.org/assets/documents/events/meetings/amsterdam_conference/decla.pdf|
|7.||↑||“First Stop TB Partners’ Forum”, Washington, 22 October 2001, 6 www.stoptb.org/events/meetings/partners_forum/2001/|
|8.||↑||“What is the GDF?”, www.stoptb.org/gdf/|
|9.||↑||“DOTS-Plus & the Green Light Committee”, www.who.int/tb/publications/2000/en/index.html|
|10.||↑||“TB Alliance History and Impact”, http://www.tballiance.org/about/history.php|
|11.||↑||“First Stop TB Partners’ Forum”, Washington, 22 October 2001, 6 www.stoptb.org/events/meetings/partners_forum/2001/|
|12.||↑||“First Stop TB Partners’ Forum”, Washington, 22 October 2001, 6 www.stoptb.org/events/meetings/partners_forum/2001/|
|13.||↑||“The Global Plan to Stop TB 2006-2015”, WHO, Geneva, 2011, 9 www.stoptb.org/global/plan/|
|14.||↑||“The Global Plan to Stop TB 2006-2015: Progress Report 2006-2008”, WHO, 2009 www.stoptb.org/resources/publications/plans_strategies|
|15.||↑||“The Global Plan to Stop TB 2011-2015”, WHO, Geneva, 2010 www.stoptb.org/global/plan/|
|16.||↑||“WHO Calls Tuberculosis a Global Emergency”, Los Angeles Times, 1993 //articles.latimes.com/1993|